Controlled Rate Freeze Thaw - CRFT

Ensure precise, programmable freeze-thaw control without liquid nitrogen, ideal for sensitive biological samples

About the CRFT

The Grant Controlled Rate Freeze Thaw (CRFT) is a liquid nitrogen free system offering precise, reliable temperature control for freezing and thawing applications.

It is ideal for applications including gamete cryopreservation, tissue culture, and stem cell research, biopharmaceuticals, vaccines, and cell therapies.

With its user defined programming, real-time data logging, and robust design, this system ensures consistent and repeatable results, minimising sample loss while maximising efficiency.

Key benefits include liquid nitrogen-free operation, low running costs, interchangeable heads for various sample types, and easy integration into automated systems, offering full flexibility for research or production environments.

Trusted by leading laboratories, the CRFT enhances productivity, reduces risk, and ensures optimal sample integrity.

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Dimensions (mm) -wdh
345 x 290 x 380 (lid off) / 460 (lid on)
Weight (kg)
5kg
Max plate temp (°C)
30°C
Min plate temp (°C)
-100°C*
Temp accuracy
+/- 0.5°C
Temp stability
+/- 0.1°C
Temp uniformity
+/- 1.0°C Ref
Max cooling rate
10°C min/min
Max thawing rate
10°C/min from -100°C
Max temp stabilisation time
5 mins
Plug type
UK, EU or US
Power supply
100-240V, 50-60Hz (24V DC unit supply)
Warranty
2 years
*Head dependant, temperature ranges of interchangeable head only, not sample. If you want to discuss your application please email our technical sales team on [email protected]
H00
Head for 16x 0.5ml straws
H01
Head for 18x0.3ml IMV straws
H02
Head for 55x1.8ml cryovials (0.5ml max fill)
H03
Head for Flat universal plate
H05
Head for 1x SBS microplate
H06
Head for 55x1.8ml deep cryovials (1ml max fill)
CRFTCRYOPEN
Cryopen nucleating tool
CRFTCARTRIDGE
Replacement cartridge for cryopen
CRFT UPS
Un-interruptible Power Supply for the CRFT for a 3 hour cycle in the event of an electrical power failure. 220-240v operation
CAL CRFT
Calibration certificate – single temperature point
CRFTMAINT 1
1 year maintenance agreement includes clean and test report(excludes repair and replacement of faulty parts)
CRFTCOMM
External communications protocol specification for the CRFT
IQOQCRFT
IQOQ booklet for CRFT
PQ CRFT
PQ booklet for CRFT
download
CRFT Software
download
CRFT Evaluation Report
download
CRFT Flyer
download
CRFT Operating Manual
download
Research Paper - The development of the cell cryopreservation protocol with controlled rate thawing

Organoids

In organoid research, the Grant CRFT system is an invaluable tool for preserving and recovering delicate organoid samples. Organoids, which mimic real organ tissues, require precise temperature control during freezing and thawing to maintain their structural and functional integrity. The CRFT system provides programmable, controlled-rate freezing, ensuring gradual cooling to avoid ice crystal formation that could damage the organoids. During thawing, the system’s precise control minimizes thermal shock, preserving cell viability and function. With real-time data logging and versatile sample compatibility, the CRFT ensures high reproducibility and reliable results, making it essential for advancing organoid-based research.

Cell culture

In cell culture research, the Grant CRFT system offers precise temperature control, ensuring the safe cryopreservation and recovery of sensitive cell lines. Its programmable freezing protocols prevent ice crystal formation, protecting cell membranes and maintaining higher viability post thawing. The system’s real-time data logging allows for repeatable, reliable freezing and thawing processes, which are critical for maintaining cell function and consistency across experiments. By preserving cell cultures without compromising quality, the CRFT system supports high-throughput research, enabling efficient, scalable cell culture storage and recovery.

Additionally, the system enables you to research optimal thawing protocols, facilitating the refinement of cryopreservation techniques to further improve cell recovery rates and viability.

GMP

For GMP applications, the Grant CRFT system ensures compliance with stringent regulatory standards while offering precise, controlled cryopreservation for critical biological materials. Its programmable freezing rates and precise thawing protocols minimize risk of contamination and maintain the integrity of sensitive products, such as cell therapies, vaccines, and biopharmaceuticals. The system’s real-time data logging and audit trail features support full traceability and documentation, which are essential for GMP environments. The CRFT offers consistent, reliable and traceable performance and a hands free alternative to traditional cryopreservation methods.